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Born in Wales in 1965, the son of Irish immigrants, Regan moved back to Ireland with his parents when he was 18, and has since starred in acclaimed television projects in both Britain and Ireland. In the last few years he has been seen in the series Hustle, Plan Man, Messiah II and Rescue Me. He has starred in several miniseries, including 40, with Eddie Izzard, Rebel Heart, opposite James Darcy, and with Fred Ward in Invasion Earth.

In 1999 Regan received an Irish Best Actor nomination for his performance in the award-winning miniseries Eureka Street, about a group from Northern Ireland who try to make their way in life in the face of sectarian and political polarization. Additional television appearances include Jeremiah, with Patrick Dempsey, Murphy's Law, with James Nesbitt, and Call Red.

Regan recently appeared with Brad Pitt in the war epic Troy, with Eric Bana and Orlando Bloom. He also starred on the big screen with Martin Lawrence in the adventure comedy Black Knight, and in Luc Besson's The Messenger: The Story of Joan of Arc and Unleashed. The versatile actor has worked in feature films in the United Kingdom as well, including Point Men, Ordinary Decent Criminal and Hard Men.

In addition to acting, Regan is a screenwriter and director, and develops projects for his own fledgling film company. Currently he is working on the BBC's Macbeth.

Regan resides in London, where he enjoys cooking and spending time with his wife, actress Amelia Curtis, and his twelve-year-old daughter, Chloe.