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Chad Lowe became a household name with his first series regular role on the ABC drama Life Goes On. For his work on the series, portraying AIDS victim Jesse McKenna, Lowe earned an Emmy Award for Best Supporting Actor on a Drama Series.

Lowe began his career as an actor in the 1980s with a series of telefilms, including Flight 90: Disaster on the Potomac, Silence of the Heart, April Morning and An Inconvenient Woman. He also starred in the telefilm Take Me Home: The John Denver Story as John Denver, and had recurring roles on such series as Melrose Place, Popular, Now and Again and ER, and guest-starring roles on such shows as Touched by an Angel, Superman, CSI: Miami and Medium, among others. Lowe recently had a recurring role on the popular series 24, playing Reed Pollock, deputy secretary to Thomas Lennox, played by Peter MacNicol.

Not relegating his work to television, Lowe ventured into the feature world, with roles in Nobody's Perfect, True Blood, Quiet Days in Hollywood, Floating and Unfaithful, opposite Diane Lane and Richard Gere. Also active in the theater, Lowe has appeared in stage productions of Huck Finn at the Williamstown Theatre Festival in Williamstown, Pennsylvania; Grotesque Love Songs at the WPA Theatre in New York; and Burning Blue at Beckett Theatre in New York.

As a director, Lowe has helmed episodes of Brothers and Sisters, Bones, Law & Order: Special Victims Unit, Hack and Without a Trace. His original short film The Audition was produced for Showtime, followed by the short The Space Between, which appeared at both the Toronto International Film Festival and the Tribeca International Film Festival. He made his feature film directing debut with Beautiful Ohio, an ensemble film starring William Hurt, Julianna Margulies, Rita Wilson, Michelle Trachtenberg and others. Lowe produced and directed the film, written by Ethan Canin (The Emperor's Club), which spotlights a family that comes of age during the turbulent Watergate Era of the early 1970s. Beautiful Ohio premiered at the 2006 AFI Film Festival in Los Angeles.