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Reprising his role as Lizzie's father on the hit Disney Channel series Lizzie McGuire, Hollywood native Robert Carradine (Sam McGuire) first appeared in such feature films as Martin Scorsese's Mean Streets, the Oscar- winning Coming Home, Joyride, The Big Red One, and The Long Riders. In 1984, he originated the well-known role of Lewis Skolnick in the film comedy Revenge of the Nerds with Anthony Edwards, and also starred in that film's sequels Nerds in Paradise, The Next Generation, and Nerds in Love, the last of which earned him a co-producing credit. His other motion picture credits include John Carpenter's Escape from L.A., Robert Altman's The Player, and Christopher Coppola's Gunfighter. Carradine most recently appeared in Who'll Stop the Rain and The Ghosts of Mars. He made his feature debut with John Wayne in The Cowboys.

On television, Carradine was in Disney Channel's original movie Mom's Got a Date with a Vampire and in the acclaimed HBO films Somebody Has to Shoot the Picture, Conspiracy: The Trial of the Chicago Eight, and Double Crossed as well as Showtime's Body Bags and As Is, for which he earned a CableACE nomination. His other telefilms and mini-series include The Tommyknockers, I Saw What You Did, The Sun Also Rises, Monte Carlo, and The Incident, with Walter Matthau.

Carradine also had a recurring role as Dr. Bruce Hartman in the action drama Nash Bridges, and guest-starred on The Practice, ER, Kung Fu, and NYPD Blue.

A member of the Carradine acting dynasty, Robert Carradine's father, renowned actor John Carradine, is a veteran of over 500 films and is featured in a number of Hollywood's classic movies, including Stagecoach, The Grapes of Wrath, and Captains Courageous, and also portrayed Dracula in the classic films House of Frankenstein (1944) and House of Dracula (1945). Carradine's brothers are David and Keith; his niece is Martha Plimpton and his daughter is Ever, who had a recurring role on Once and Again.