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Anne Heche portrays Rebecca Payne in John Q, the tough hospital administrator. In the summer of 2000, Heche wrapped a supporting role in Erik Skjoldbjærg's Prozac Nation, starring Christina Ricci. She also co-starred in Auggie Rose with Jeff Goldblum, selected for the Montreal Film Festival. Heche recently starred in Agnieska Holland's The Third Miracle, opposite Ed Harris, and in Gus Van Sant's Psycho, opposite Vince Vaughn and Julianne Moore. She starred opposite Vaughn in Return to Paradise and opposite Harrison Ford in Six Days, Seven Nights.

Heche won The National Board of Review Award for Best Supporting Actress in Barry Levinson's Wag the Dog, with Robert DeNiro and Dustin Hoffman. She starred opposite Tommy Lee Jones in Volcano and was featured, to much acclaim, opposite Johnny Depp and Al Pacino in Donnie Brasco. She has also starred in The Juror, Walking and Talking and HBO's If These Walls Could Talk, directed by Cher. Her other film credits include The Wild Side, Pie in the Sky, Twist of Fate, Milk Money, The Investigator, I'll Do Anything, The Adventures of Huckleberry Finn and Ambush of the Ghosts.

Heche wrote and directed Reaching Normal, a short for Showtime's First Director Series, as well as the second installment of If These Walls Could Talk II, starring Sharon Stone and Ellen DeGeneres. She won an Emmy Award for her performance on television's Another World and recently appeared in a 1-episode story arc on Ally McBeal. In September 2001, she published her autobiography Call Me Crazy, which appeared on The New York and Los Angeles Times' best-seller lists.