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Melanie Mayron made her directing debut on the set of her hit ensemble show thirtysomething and later marked her feature directorial debut with The Babysitter's Club. Television credits include the remake of Freaky Friday and Toothless, a two-hour premiere film for The Wonderful World of Disney, starring Kirstie Alley and Lynn Redgrave, for which Mayron garnered a Directors Guild Award nomination. Additionally, she has directed episodes of Dawson's Creek, Nash Bridges, Arli$$, The Larry Sanders Show, Providence and Ed. Mayron also directed the pilot and several episodes of A State of Grace for ABC Family. She is currently co-producing the film Let It Ride with Gale Ann Hurd.

As an actress, Mayron, a native of Philadelphia, studied at the American Academy of Dramatic Arts in New York and is best known for a series of lauded performances in highly visible projects: Claudia Weill's critically acclaimed Girl Friends, for which Mayron was nominated for a British Academy Award; Costa Gavras' controversial Missing; and opposite Vanessa Redgrave in Arthur Miller's Playing for Time. She was one of the regular cast members on ABC's Emmy Award-winning series thirtysomething and received an Emmy for her work on the show. She starred on Broadway in Herb Gardner's The Goodbye People and later created the role of Isabelle Off-Broadway in Susan Sandier's Crossing Delancey. Additional work includes" Ordeal in the Arctic with Richard Chamberlain; Other Women's Children; Drop Zone with Wesley Snipes; the independent film Sticky Fingers with Helen Slater, which Mayron also co-wrote and co-produced; as well as the award-winning short Little Shiny Shoes. She has been seen in Mad About You, Wasteland and Clockstoppers.